Specificity of Dendris

Innovation and differentiation
of Dendris test


A TRIPLE COMBINATION

A key parameter in DNA microarray technique is the sensitivity and specificity of the interaction between probes and targets, which is a compromise between the “probes”’ design and the chemistry of the support onto which the probes are fixed. Also the sensitivity is dependent on the quality of the target including its biological origin, sampling/extraction, labelling and hybridization conditions. Our technology is based on the functionalisation of the support by phosphorus dendrimers. This technology dramatically increases the sensitivity of our DendrisChips.

Figure 3 clearly illustrates the originality of this technology to fabricate our DNA chips termed DendrisChip (red line), as the patterning of the glass side onto wich the probes are linked provinding sensitivity i.e  a capacity to detect interaction of a probe with a target that is 10 to 100 times higher than the others with any commercially available funnctionnalized glass slides, used by other potential competitors.